Single-dose nirsevimab prevents RSV infection

Mucosal delivery of a double-stapled RSV peptide prevents nasopulmonary infection.

Respiratory syncytial virus (RSV) infection accounts for approximately 64 million cases of respiratory disease and 200,000 deaths worldwide each year, yet no broadly effective prophylactic or treatment regimen is available. RSV deploys paired, self-associating, heptad repeat domains of its fusion protein, RSV-F, to form a fusogenic 6-helix bundle that enables the virus to penetrate the host cel...

Respiratory Syncytial Virus (RSV) Infection

A single dose of dalteparin effectively prevents clotting during haemodialysis.

BACKGROUND A single bolus dose of LMW heparin at the start of haemodialysis effectively prevents clot formation in the dialyser and bubble trap. However, there are few studies on the appropriate dosage of LMW heparins in haemodialysis. Therefore we examined the relationship between the anticoagulant effect of dalteparin and clinical clotting during haemodialysis. METHODS We performed an open,...

Single dose trimethoprim for urinary tract infection.

A randomised clinical trial of single dose trimethoprim against a seven day course of co-trimoxazole (trimethoprim/sulphamethoxazole) for the treatment of uncomplicated urinary tract infection was carried out in 106 children aged between 2 and 16 years. Of the 50 children with confirmed urinary tract infections who were followed up 48 hours after treatment with a single dose of trimethoprim all...

Interactions between RSV Infection, Asthma, and Atopy

In this issue, Culley et al. (1) present findings from an infant mouse model of respiratory syncitial virus (RSV) infection , which provides a new perspective on the patho-genesis of RSV-mediated lung disease in early life. RSV is one of the most common respiratory pathogens encountered in pediatric practice, and virtually all children experience one or more infectious episodes by the age of 2 ...